| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 represents H, alkyl, cycloalkyl, phenyl, (phenyl-substituted) alkenyl or (lower alkoxy-substituted) phenyl lower alkyl; R 2 represents H or lower alkanoyl; R 3 to R 6 represent H or alkyl, provided that at least one of R 2 to R 6 represents group other than H when R 1 represents methyl, ethyl, isopropyl or t-butyl]. n EXAMPLE: Tetraethyl [(5-methyl-3-isoxazolyl)amino]methylene bis(phosphonate). n USE: A bone resorption inhibitor and anti-anthritis agent. n PREPARATION: A 3-amino-isoxazole expressed by formulae II or III, a lower alkyl orthoformate expressed by formula IV and a phosphorous acid ester expressed by formulae V or VI are subjected to reaction preferably at 150°C for 10-60min. n COPYRIGHT: (C)1990,JPO&Japio |