| abstract |
PURPOSE: To obtain a composition for treating and preventing dermatosis, especially ichthyotic dermatosis and hyperkeratosis, containing a specific pyroglutamic acid ester. n CONSTITUTION: This composition comprises a compound of formula I [R is a 1-30C alkyl or a group of formula II; R' and R" are each H or a group of formula III ((u) and (v) are each 0 or 1; (w) is 0-21; (x) is 0-4; (y) is 0-2; (z) is 0-4; u+v+w+x+y+z is 1-22 with the proviso that the value is 10-22 when CH=CH exists)] as an active ingredient. The composition is effective for treating ichthyotic dermatosis, Conradi's syndrome, local hyperkeratosis, head seborrheic dermatosis, callosity forming disease, psoriasis, eczema, xerosis, verruga, athlete's foot, other dermatomycosis, rosy seborrhea pimple, white seborrhea pimple, flat lichen, chronic simple lichen, alopecia cicatrisata followed by scalp dry flake formation, Darier disease, other itches, dermatitis seborrheica, edema, acne, mange, alopecia, etc. n COPYRIGHT: (C)1990,JPO |