| abstract |
NEW MATERIAL: A compd. represented by formula I [wherein R 1 and R 2 are each H, a 3-8C cycloalkyl, a 1-12C alkyl or a (substd.) phenyl; R 3 and R 4 are each a (substd.) 1-8C alkyl; X is a 1-12C hydrocarbon and O, S, N and the like may be interposed any time; and Y is pyridyl or NR 9 R 10 (R 9 and R 10 are each H or a 1-12C alkyl)]. n EXAMPLE: N-Ethyl 3-(2-N-benzyl-N-methyl-ethoxycarbonyl)-1,4-dihydro-2,6- dimethyl-4-(3-nitrophenyl)pyridine-5-carboxyamide hydrochloride represented by formula II. n USE: An inhibitor of hypertension and heart function failure. n PROCESS: An aldehyde represented by formula III and a β-ketocarboxylic acid ester represented by formula IV are isolated from a ylidene compd. generated therefrom if necessary and subsequently reacted with a β-ketocarboxylic acid represented by formula VI and ammonia. n COPYRIGHT: (C)1990,JPO |