| abstract |
NEW MATERIAL:A compound shown by formula I (n is 2-11) and a pharmaceutically acceptable salt thereof. n EXAMPLE: Apovincaminic acid 3-nitroxy-n-propyl ester. n USE: A remedy for cerebrovascular disease, peripheral blood vessel disorder, angina pectoris, hypertension, etc. n PREPARATION: Apovincaminic acid is reacted with thionyl chloride, etc., in an inert solvent such as dichloroethane to give an acid chloride, which is reacted with a compound shown by formula II in an inert solvent in the presence of a base (e.g. triethylamine) in a temperature range at 0°C-boiling point of solvent for 1-12 hours to give a compound shown by formula I. n COPYRIGHT: (C)1990,JPO&Japio |