| abstract |
PURPOSE: To obtain a therapeutic agent for proliferative dermatitis, capable of inhibiting proliferation of epidermal cell, especially keratinocyte, comprising a transforming growth factor-β(TGF-β) as an active ingredient. CONSTITUTION: This proliferation inhibiting composition for proliferative epidermal cell comprises a fraction containing at least one TGF-β (TGF-β1 and TGF-β2) or at least eight amino acids of complete sequence of TGF-β, generally at least 35 amino acids in a series as an active ingredient. The composition is effective for inhibiting proliferation of keratinocyte induced by cytokinin (e.g. TGF-α, IL-1 or EGF). TGF-β or its analog is added to a cream for application to skin or an ointment base, pharmaceutically manufactured and is preferably mixed with an epidermis permeation enhancer (e.g. dimethyl sulfoxide). |