| abstract |
NEW MATERIAL: A compd. represented by formula I (wherein R 1 is H or alkyl, R 2 is groups represented by formulae II-IV (wherein R 3 -R 6 are each H, halogen, NO 2 , alkyl, alkoxy, alkoxycarbonyl, dialkylamino, alkylthio, alkylsulfynyl, alkylsulfonyl or halogenoalkyl; X is O, S, SO or SO 2 ; and Ar is aryl which may be substituted)] and its acid addition salt. n EXAMPLE: 4-[2,4-Dimethylphenoxy) phenyl]-2-[2-(2,4-dimethylphenoxy) phenyl]-2-[2-(2,4-dimethylphenoxy) phenyl]-2-[2-(1,4,5,6- tetrahydropyrimidinylamino]thiazole. n USE: An antifungal agent. n PROCESS: A thiourea deriv. represented by formula V is reacted with an acetophenone deriv. represented by formula VI (E is OH or halogen) in the presence of a diluent if proper and in the presence of a reaction auxiliary agent if proper to obtain the compd. represented by formula I. n COPYRIGHT: (C)1990,JPO |