http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H02164858-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_382ccfc2ebebcaee15aa7cda4cee86bc |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate | 1988-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f137029f448ce3e945fbc2f2b1c1cd7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8249d56ea370f3483a18e123eb28683c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627d68e742e40baf30a5a38fe87494f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79482cdbb998e5892c120632db5cf851 |
| publicationDate | 1990-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H02164858-A |
| titleOfInvention | Production of benzene derivative |
| abstract | PURPOSE: To readily obtain a compound useful as synthetic intermediate of anti-arhythmia agent with short process in high yield using reagent of low cost and without malodor by reacting amine and halocarboxylic acid, etc., and acting halogenation agent. n CONSTITUTION: Amine expressed by formula I (R 1 is H, lower alkyl, lower alkoxy, halogen, halo-lower alkyl or nitro; R 2 is lower alkyl or lower alkoxy) is reacted with halocarboxylic acids expressed by the formula X 1 CH 2 COX 2 (X 1 is halogen; X 2 is OH or halogen) in ordinary amide bonding-generation reaction to obtain a compound expressed by formula II. Then, the compound is reacted with halogenation agent in a solvent such as methylene chloride at a temperature from -80 to 100°C for 0.5-3 hour to afford the aimed compound expressed by formula III. In the reaction, amount of the halocarboxylic acids is 1-1.5mol times to amine and amount of the halogenation agent is 1-10mol times to the compound expressed by formula II. n COPYRIGHT: (C)1990,JPO&Japio |
| priorityDate | 1988-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 18.