| abstract |
NEW MATERIAL: A compd. represented by formula I [wherein A is O or S, B is 3-8C alkylene or a group represented by formula II (wherein R is H, halogen or lower alkyl), D is carboxy or tetrazolyl and, when A is S, B is the group represented by the formula II and, when A is O, D is tetrazolyl]. n EXAMPLE: 2,6-di-t-butyl-4-[(4-cyanophenyl)-methoxy]phenol. n USE: Antiallergic drug and its synthesizing intermediate. This new material has leucotriene synthesis inhibiting action. n PROCESS: 2,6-di-t-butyl-1,4-hydroquinone represented by formula III is reacted with a metal hydride to be converted to a salt which is, in turn, reacted with a haloalkylnitrile or halobenzylnitrile and the reaction product is reacted with sodium azide, ammonium chloride and lithium chloride to obtain the compd. represented by formula I. n COPYRIGHT: (C)1990,JPO |