| abstract |
NEW MATERIAL: A compd. represented by formula I [wherein X is groups represented by formulae II-V (R 2 is II, lower alkyl or benzyl); R 1 is II or lower alkyl; and R 3 is H or R 5 -C(=O) (C 5 is lower alkyl)] and its salt. n EXAMPLE: 4[(2-Mercaptomethyl)-1-oxo-3-phenylpropyl] aminol benzoic acid. n USE: A vadodepressor agent. n PROCESS: Acylthiocarboxylic acid represented by formula VI and aminobenzoic ester or aminocyclohexane-carboxylic ester represented by formula HX are subjected to coupling reaction to obtain the compd. represented by formula I. The reaction is pref. performed in the presence of diisopropylethylamine. The compd. represented by formula VI is pref. converted to an active compd. such as acid chloride or a mixed acid anhydride. n COPYRIGHT: (C)1990,JPO |