| abstract |
PURPOSE: To provide a compd. prohibiting protease encoded by HIV useful for preventing human immunedeficiency virus(HIV) infection and treating HIV infection and AIDS. n CONSTITUTION: This HIV protease inhibitor is composed of a compd. represented by formula I {wherein A is R 1 -CO, R 1 -SO 2 , or R 1 -N (R 5 )-SO 2 (R 1 is alkyl, or aryl; and R 5 is H or alkyl); G is a group represented by formula II [Z is O, S, or NH; R 9 is H, OR or NR 2 (R is H or alkyl); and Q is groups represented by formulae III, IV]; B is independently absent or a group represented by formula V; J is YR 14 , or N(R 14 ) 2 [Y is O, or NH; and R 14 is H, alkyl, or (CH 2 CH 2 O) CH 3 ]}, for example, N'-(1,1-dimethylethylaminocarbonyl)-5(S)-amino-4(S)- bydroxy-6-phenyl-2(R)-(phenylmethyl) hexanoyl-leucyl-phenylalanylamide. n COPYRIGHT: (C)1990,JPO |