| abstract |
NEW MATERIAL:The isoquinolinesulfonamide derivative of formula I (R 1 , R 2 and R 3 are H or lower alkyl; X is H or halogen) and its acid addition salt. n EXAMPLE: N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide. n USE: A vasodilator, a hypotensor, a cerebral circulation improver, remedy for stenocardia, preventive and remedy for thrombosis of cerebrocardiovascular system and a reagent for biochemical field. It has calmodulin-inhibiting action and exhibits smooth muscle relaxation and vasodilation actions. n PREPARATION: The compound of formula I can be produced by heating an isoquinoline compound of formula II and chlorosulfonic acid in a solvent or in the absence of solvent, reacting the resultant sulfonyl compound of formula III with an amine compound of formula IV (Z is alkyl or benzyloxycarbonyl) to obtain a compound of formula V and eliminating the protecting group from the compound. n COPYRIGHT: (C)1990,JPO&Japio |