http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0215064-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6bfdf49224a405be1f7b653c56ebad94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 |
| filingDate | 1988-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd601d995dfec41a8cf1de66934bcd4f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca703534708bf4748e27f1e0f00d8322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_288b83d5dc3d3d4913cbcf24a8ecb229 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d385f70187d017c86a31864caf0dddaa |
| publicationDate | 1990-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0215064-A |
| titleOfInvention | Production of 2-chloro-6-methylaminopyridine |
| abstract | PURPOSE: To readily, industrially and advantageously obtain the subject compound useful as a synthetic intermediate for medicines and agricultural chemicals in good yield and high purity by separating a reaction product of a 2,6- dichloropyridine with methylamine into liquid layers using a specific solvent, concentrating and distilling the resultant organic layer. n CONSTITUTION: 2,6-Dichloropyridine is reacted with an aqueous solution of methylamine in a molar amount of preferably 3-4 times based on the above- mentioned compound in an autoclave at 130-150°C. A dehydrohalogenating reagent, such as NaOH, in a molar amount of 1.5-2.0 times based on the 2,6- dichloropyridine is then added to the resultant reaction solution, which is subsequently heated at 60-100°C to remove and recover the methylamine. An aromatic hydrocarbon solvent, such as toluene or ethylbenzene, in an amount of preferably 0.5-5.0 times based on the reaction product is then added to the obtained heated mixture solution after removing the methylamine at 65-100°C and below the boiling point of the aromatic hydrocarbon solvent used to carry out separation of liquid layers. The obtained organic layer is subsequently concentrated and distilled, preferably at 100-200°C under reduced pressure to afford the objective compound. n COPYRIGHT: (C)1990,JPO&Japio |
| priorityDate | 1988-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.