| abstract |
NEW MATERIAL:An L-dopa derivative expressed by the formula [either of R 1 and R 2 is H and the other is RCO (R is alkyl, alkenyl, cycloalkyl which may have a substituent group, phenyl which may have a substituent group, aralkyl which may have a substituent group, lower alkoxy or aralkyloxy which may have a substituent group)] and acid addition salts thereof. n EXAMPLE: 3-(3-Hydroxy-4-pivaloyloxyphenyl)-L-alanine. n USE: A treating agent for Parkinson's diseases capable of sustaining clinically effective blood level for a long period without causing rapid and excessive rise in blood L-dopa level in administration and further providing intracorporeal kinetics of the L-dopa with hardly any variation. n PREPARATION: L-Dopa is reacted with an acylating agent expressed by the formula RCOQ (Q is leaving group) and the existing protecting groups are then removed to afford the compound expressed by the formula. n COPYRIGHT: (C)1990,JPO&Japio |