| abstract |
NEW MATERIAL: A compound of formula I (wherein R, R 6 are each a lower alkenoxy, a di-lower alkylamino lower alkoxyl, an acylamino lower alkoxyl, etc.; R 1 is H, an alkyl, a substituted lower alkyl, phenyl, etc.; R 2 , R 7 are each H, a lower alkyl; R 3 is H, a lower alkyl, a phenyl lower alkyl, an aminomethylphenyl lower alkyl, etc.; R 4 is H, a lower alkyl; R 5 is H, a lower alkyl, phenyl, a phenyl lower alkyl, etc.). n EXAMPLE: N-[1(S)-Carboxy-3-phenypropyl]-L-alanyl-L-proline. n USE: An antihypertesive agent, a converting enzyme inhibitor. n PREPARATION: A keto acid of formula II (or an ester, amide or hydroxamic acid) is condensed with a peptide of formula III in a neutral aqueous solution or an organic solvent (e.g. CH 3 CN, etc.), in the presence of sodium cyanoborohydride. n COPYRIGHT: (C)1990,JPO |