| abstract |
NEW MATERIAL:The compound of formula I [R 1 is H, carboxyl, 1-22C alkoxycarbonyl, alkylcarbamoyl, alkoxy, amino, group of formula II (R is phenyl or aralkyl), etc.; R 2 is H, lower alkoxy, amino, etc.; R 3 is alkyl, aralkenyl, pyridyl, (substituted) phenyl, etc.], the compound of formula III and their pharmacologically permissible acid addition salts. n EXAMPLE: 2-Phenyl-4-(4-phenylpyrazin-1-ylmethyl)-5-methoxy-7,8-dihydro-7,8- dioxoquinoline. n USE: An agent for preventing peroxidation of lipid and a platelet coagulation inhibiting agent. n PREPARATION: A compound of formula III wherein R 2 is H can be produced by demethylating a compound of formula IV e.g., by treating the compound with boron tribromide in an inert solvent at -78°C to room temperature. The compound of formula I is obtained by the oxidative demethylation of the compound of formula IV with cerium ammonium nitrate, etc. n COPYRIGHT: (C)1990,JPO&Japio |