| abstract |
NEW MATERIAL: Compound of formula I {R is formula II {R 1 is oxalinyl, -C≡N, -CH 2 OR 2 (R 2 is H, 1-6C alkyl, cyclopentyl, etc.), formula III [R 3 is H, OR 4 (R 4 is H, 1-6C alkyl), etc.]}, formula IV} or its salt. n EXAMPLE: Compound given by formula V. n USE: A component of a cosmetic and pharmaceutical composition. n PROCESS: dl-Pachenol of formula VI is oxidized into dl-pachenal, which is reacted in a methyl magnesium iodide solution and oxidized further, and the product is reacted with an organomagnesium compound of formula VII in acetylene. Next, the product is reacted with ethylmagnesium bromide, a lower alkyl trans- formyl-3-buten-2-oate, hydrogenated diisobutyl aluminum, a halogenated trialkylsilyl, etc., in sequence and reduced catalytically with H 2 , and reacted with TiCl 3 and LiAlH 4 to remove two OH, to obtain a compound of formula I in which R 1 is -CH 2 OR 2 . n COPYRIGHT: (C)1990,JPO |