| abstract |
PURPOSE: To obtain a medicine composition useful for treating AIDS or preventing and treating infection with HIV, containing a specific renin inhibitor and a specific medically permissible carrier. CONSTITUTION: This compound contains a compound of formula I [R<1> is H, CONH2 , COOH, an alkyl, an aryl, etc.; R<4> is H or a group of formula II (R<3> is H, an alkyl, an aryl, etc.; R<9> is H, an alkyl, OH, etc.); A is H or a group of formula III (X is O, S, CH, etc.; R<2> a and R<2> b are each H, an alkyl, an aryl, etc.; B is absent glycyl, a group of formula IV, etc., E is absent, a group of formula V (R<5> is H, an alkyl, an aryl, etc.); (m) is 1-4; G is a group of formula VI (R<6> is an alkyl, an aryl, etc.; (q) is 1-4; Q is a group of formula VII, a group of formula VIII, etc.); J is absent, a group of formula IX, etc.; L is absent, OR" or NHR" (R" is H or an alkyl), etc.)] such as N'-acetyl-Pro-Phe-His4(S)- amino-3(S)hydroxy-6-methylheptanolGlu-Phe-Gly-amide. |