| abstract |
NEW MATERIAL:Bicyclo[3.3.0]octanes of formula I [Among R 1 , R 2 and R 3 , R 1 combined together with R 2 represents single bond and R 3 is Cl Br or I, or R 2 combined together with R 3 represents single bond and R 1 is Cl or I; R 4 and R 5 are H, tri(1-7C)hydrocarbonsilyl or form acetal bond or ester bond between those and 0 bonded thereto; R 6 is H, methyl or vinyl; R 7 is straight or branched chain 3-8C alkyl which may contain 0, phenyl, phenoxy or 3-10C cycloalkyl, etc.; n is 0 or 1]. n USE: Having a platelet aggregation inhibition effect and useful as an intermediate for synthesis of isocarbacyclin useful as a medicine. n PREPARATION: A compound of formula II [R 41 and R 51 are tri(1-7C) hydrocarbonsilyl, etc.] is halogenated and subjected to a reaction for removal of a protective group as necessary to provide a compound of formula I. n COPYRIGHT: (C)1990,JPO&Japio |