http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H01319482-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21a39b3e9cbd64f50e4548ff455b6e89 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 1988-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a432a11948d3b2cc739b124edc91e24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af938c285baf79fbb5952c053c6f0346 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d48a7595b0d9bea8ae6a875432e7fd9 |
| publicationDate | 1989-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H01319482-A |
| titleOfInvention | Production of 7-bromo-beta-carboline derivative and intermediate therefor |
| abstract | PURPOSE: To obtain the subject substance useful as an intermediate for synthesis of alkaloids in high yield and selectivity by reacting a specific β-carboline derivative with a brominating agent in an organic solvent in the presence of an alkali and stirring the product in the presence of an acid to carry out rearrangement reaction. n CONSTITUTION: A β-carboline derivative expressed by formula I (R 1 represents H or 1-5C alkyl; R 2 represents 1-5C alkyl or benzyl; R 3 represents H, alkyl, alkoxy or benzyloxy) is reacted with a brominating agent (preferably bromine or N-bromosuccinimide) in an organic solvent (example; dichloromethane) in the presence of an alkali to afford a 4a-bromo-β-carboline derivative expressed by formula II, which is then stirred in the presence of an acid (example; hydrobromic acid) to achieve rearrangement reaction and afford the objective compound expressed by formula III. n COPYRIGHT: (C)1989,JPO&Japio |
| priorityDate | 1988-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.