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filingDate 1988-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6667c121301a2566ba881a2c038428ee
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publicationDate 1989-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H01319468-A
titleOfInvention Production of thiazolecarboxylic acid chlorides
abstract PURPOSE: To obtain the present compound of a raw material for medicine and agricultural chemical in short reaction time without treatment of by-product by using a catalyst in reaction of thiazole-carboxylic acids with phosgene or trichlroromethylchloroformate. n CONSTITUTION: Thiazolecarboxylic acids (e.g., thiazole-5-carboxylic acid) expressed by formula I (R 1 is H, halogen, lower alkyl, lower alkoxy or lower alkyl substituted by halogen or lower alkoxy group; R 2 is H, lower alkyl or lower alkyl substituted by halogen or lower alkoxy group) is reacted with phosgene or trichloromethylchloroformate, in the presence of a catalyst, preferably using the latter compound of 1.0-5.0mol based on 1mol compound expressed by formula I in a solvent such as benzene to provide the compound expressed by formula II. As the above-mentioned catalyst, N,N-dimethylformamide, etc., is preferably used at an amount of 0.1-1wt.% based on the compound expressed by formula I. n COPYRIGHT: (C)1989,JPO&Japio
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