| abstract |
NEW MATERIAL: Compds. of formula I [wherein R 1 represents H or CH 3 ; R 2 represents 4(4-methyl-2-thiazolyl)piperazino or the like; and R 3 represents a 1-4C alkoxyl, NH 2 or 1-4C alkylamino] and acid addn. salts of them. n EXAMPLE: 5-[1-hydroxy2-(4-(4-methyl-2thiazolyl)piperazino)ethyl]salicylamide. n USE: Hypotensive drug. n PREPARATION: Compds. of formula I are obtained by, for example, reacting a compd. of formula II (wherein Z represents -CHOH-CHR 1 or a group of the III; and X represents Cl, Br, I or the like) with a base of the general formula: H-R 2 . n COPYRIGHT: (C)1989,JPO |