| abstract |
NEW MATERIAL: A compound of formula I [R 1 is OH, 1-6C hydroxyalkyl, 1-6C carboxyalkyl, phenyl, oxo, amino, carboxy, amide, etc.; R 2 , R 3 are each 1-6C alkyl, 3-6C alkenyl or -N R 2 R 3 forms five- or six-membered ring (containing O adjacent to N); X is directly bonded, -CH 2 -, -CH 2 O-; Ar is substituted phenyl] and its salt. n EXAMPLE: 8-[(3,4-dichlorophenyl) acetyl]-7-(1pyrrolilidinylmethyl)-1,4-dioxa8- aza[4,5]spiro decane hydrochloride. n USE: Drug, being selective kappa-opioud acceptor agonist to be used for curing pain or cerebral anemia. n PROCESS: For example, a compound of formula I is obtained by reacting a compound of formula II with an acid of a formula ArXCOOH or a reagent useful to introduce an acylating agent corresponding to the acid or its salt group -COXAr. n COPYRIGHT: (C)1989,JPO |