| abstract |
NEW MATERIAL:A compound expressed by formula I (R 1 ls lower alkyl; R 2 is aryl, cycloalkyl or heterocyclic group; R 3 is H, lower alkyl, lower alkenyl or acyl; R 4 is H, lower alkyl or hydroxyalkyl; R 5 is H, lower alkyl, halogen or protected amino; n is 1 or 2) and salts thereof. n EXAMPLE: 1-Methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline. n USE: An anticonvulsant agent and delayed neurocyte necrotic inhibitor. n PREPARATION: A compound (novel substance) expressed by formula II (R 6 is amino-protecting group) or salts thereof are subjected to eliminating reaction of the amino-protecting group to afford the aimed compound expressed by formula I (R 3 is H), etc. n COPYRIGHT: (C)1989,JPO&Japio |