| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 is acetyl or benzyl; R 2 is methyl; R 3 and R 4 are H or R 1 ; R 5 is -COC(CH 3 ) 3 , formula II, etc.; R 6 is H, formula III (Bz is benzyl), etc.]. n EXAMPLE: A compound expressed by formula IV (Ac is acetyl; Bn is benzyl; -CO + is pivaloyl). n USE: An intermediate useful for synthesis of ganglioside GM 3 and capable of synthesizing ganglioside GM 3 in high yield. n PREPARATION: A raw material compound expressed by formula V is treated with tris-triphenylphosphine rhodium (I) chloride and 1,4-diazabicyclooctane and the resultant product is reacted with carbon tetrabromide to provide a compound expressed by formula VI. Then a compound expressed by formula VII obtained from the compound expressed by formula VI is successively subjected to deacetylation, benzylation, treatment by (trimethylsilane)-triflate and deacetylation to give a compound expressed by formula VIII, which is further treated with trimethylacetyl-chloride-dimethylaminopyridine and the resultant product is deprotected. n COPYRIGHT: (C)1989,JPO&Japio |