http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H01272595-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fec576c38e34882531ca37d6b922bf42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 1988-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd9c94cb75c25d75b0c5734b72b5af4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a8a1589ee64d17d93af0e487c281c75 |
| publicationDate | 1989-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H01272595-A |
| titleOfInvention | Production of 2'-deoxy-5-fluorouridine-diacyl derivative |
| abstract | PURPOSE: To efficiently obtain the subject compound useful as an antineoplastic agent, etc., by a small number of processes, by reacting 2'-deoxyuridine with fluorine gas in an aqueous solution and subsequently with a carboxylic anhydride or halide. n CONSTITUTION: For example, 2'-deoxyuridine is added to an aqueous solution containing a carbonate so as to be 3-20% concentration and reacted with fluorine gas diluted with nitrogen, helium, etc., preferably at 0-25°C to prepare 2'-deoxy-5,6-dihydro-5-fluoro-6-hydroxyuridine. To 1mol of the resultant compound, 4mol of a carboxylic anhydride or halide of formula I [R is ≤20C aliphatic hydrocarbon or (substituted)phenyl; X is acyloxy or halogen expressed by RCO 2 ], an organic base, etc., are added and heated, thus obtaining the objective compound of formula II. n COPYRIGHT: (C)1989,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004065403-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7388094-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2004323518-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004089968-A1 |
| priorityDate | 1988-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.