| abstract |
NEW MATERIAL:A compound shown by formula I (R is 1W10C alkyl, 6W10C aryl or 1W10C hydroxyalkyl; R' is 1W10C alkyl, 6W10C aryl, 1W10C hydroxyalkyl or 1W6C alkoxy). n EXAMPLE: (-)-1,1-Difluoro-2-hydroxypropan-1-yl phenyl ketone. n USE: Liquid crystal, various kinds of drugs including anti-cancer drug and a synthetic intermediate thereof having extremely high optical purity. n PREPARATION: An α,α-difluoro-β-hydroxycarbonyl compound shown by formula II having no optical activity is processed into an acylated material shown by formula III (COR' is acyl), which is asymmetrically hydrolyzed with an enzyme such as lipase to give a compound shown by formula I. n COPYRIGHT: (C)1989,JPO&Japio |