http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H01221330-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45de8ecea49bd1a37ae21cf258fdca54 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-0023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L2-00 |
| filingDate | 1988-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_134cae85c7fffdeb53c5644e2bca833d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bb8ff66b62652331c191fa46bd847e1 |
| publicationDate | 1989-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H01221330-A |
| titleOfInvention | Sterilization of composition having limited stability |
| abstract | PURPOSE: To sterilize a material compounded with a thermolabile agent under a physiological pH condition by using a buffer solution of a weak acid providing a physiological pH and lowering the pH with a carbonic acid salt and to safely sterilize the above agent at a high temperature by removing carbon dioxide from the above mixture to return the pH of the system to the physiological pH. n CONSTITUTION: A thermolabile pH-sensitive composition in an aqueous mixture is easily and effectively sterilized by preparing a mixture containing (A) the above composition, (B) an aqueous medium buffered to a pH of ≥5.5 or thereabout with a buffer solution other than an amine nitrogen buffer solution, preferably an organic carboxylate buffer solution (especially citrate buffer solution) having a concentration of about ≤50mM and (C) CO 2 of an amount sufficient to lower the pH to about ≤5.5, preferably to 4-5, sterilizing the obtained mixture under a sterilizing condition, preferably at about 121°C for 20min and removing the CO 2 from the mixture to equilibrate the pH of the mixture to a pH of >5.5, preferably to 6-7. n COPYRIGHT: (C)1989,JPO |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008229353-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008212695-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11185598-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2008146731-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013522344-A |
| priorityDate | 1987-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.