| abstract |
NEW MATERIAL:A thioimidazole derivative of formula I (R 1 , R 2 are lower alkyl; or R 1 and R 2 incorporate to form together with N a 5-W7-membered ring, which may contain N, S, and O where the ring may be substituted with lower alkyl or lower alkoxy; R 3 is H, lower alkyl, cycloalkyl, phenyl, lower alkylcarbonyl or R 2 and R 3 incorporate to form a carbonyl ring; R 4 is H, lower alkyl, lower alkoxycarbonyl; R 5 is lower alkyl, lower alkoxy, phenyl, H) and its acid adducts. n EXAMPLE: 2-(N,N-Dimethylcarbamoylthio)-4-phenylimidazole. n USE: A brain function improver having anticerebroischemic and antihypoximic actions. n PREPARATION: The reactions are carried out as shown in the equations to give the compound of formula I. n COPYRIGHT: (C)1989,JPO&Japio |