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filingDate 1988-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ab06759c62d9b2dd933cd550859ce12
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publicationDate 1989-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H01199979-A
titleOfInvention Novel quinolinecarboxylic acid derivative and antibacterial agent comprising said compound as active ingredient
abstract NEW MATERIAL:A compound shown by formula I (Z is group shown by formula II or formula III; R<1> is H or lower alkyl; R<3> is H, OH or lower alkyl; R<3> is H, OH or amino). EXAMPLE:9,1-Epoxymethano-7-fluoro-8-(4-methyl-1-piperazinyl)-5--oxo-5H -thiazolo [3,2-a]quinoline-4-carboxylic acid. USE:Having strongly antibacterial activity against Staphylococcus aureus having methicillin resistance. PREPARATION:(B) A compound shown by formula II is reacted with (C) a cyclic amine (ZH) or an acid addition salt thereof in (A) a polar organic solvent such as dimethyl sulfoxide in the presence of an acid scavenger.
priorityDate 1987-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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