http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H01197431-A

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filingDate 1988-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4374dbaa9a739717f9576e142bfcc745
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publicationDate 1989-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H01197431-A
titleOfInvention Liposome including antibiotic
abstract PURPOSE: To obtain liposome including an antibiotic which is used in treatment for intractable infectious diseases, by allowing the liposome to include an antibiotic and coating the liposome with a polysaccharide derivative occurring in nature on its surface. n CONSTITUTION: An antibiotic, preferably ampicillin or minocycline is included inside the liposome whose membrane is composed of a phospholipid or a combination thereof with cholesterol. Then, the liposome is coated with a natural polysaccharide derivative such as mannan or amylopectin on its surface. The polysaccharide derivative is substituted 0.5W5 primary alcohol groups per 100 units of the monosaccharides with cholesteryloxycarbonyl- aminoethylaminocarbonylmethyl groups. Natural release of the antibiotic included inside is controlled and the efficiency is improved in the transfer of liposome into cells. n COPYRIGHT: (C)1989,JPO&Japio
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