| abstract |
NEW MATERIAL: The compounds of formula I {R 1 is 1-4C alkyl, 2-4C alkenyl, alkynyl or the like; n is 0-3; Z form heterocyclic ring bonding C and N and having 5-8C ring or the like; R 2 is formula II [B is -CO-; C is O, NR 6 (R 6 is H or the like); D is formula III (m is 0-2; R 7 is C ring in which one of C is substituted by the second or third N or its N-oxide.]; R 3 is H, halogen, or the like}. n EXAMPLE: (5,6-Dihydro-4H-pyrrolo-[3,2,1-i,j]-quinolinyl-1)carboxylic acid (endo-8- metyl-8-azabicyclo-[3,2,1]-octyl-3]ester hydrochloride. n USE: Pharmaceuticals, which are useful for treating syndromes caused by excessive stimulation of 5-hydroxytryptamine receptors. n PROCESS: For example, the compounds of formula IV (X is a group which is substitutable by nucleophilic group) is reacted with the compound of formula V (Y is H or alkali metal) to obtain the compound of formula I. n COPYRIGHT: (C)1989,JPO |