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filingDate 1988-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b4badd99f78ecaa3cecb969d3f0207c
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publicationDate 1989-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H01180849-A
titleOfInvention Method for concentrating and separating docosapentaenoic acid or ester thereof
abstract PURPOSE: To efficiently concentrate and separate the title compound useful in the pharmaceutical field in a large amount, by concentrating a more highly unsaturated fatty acid, etc. than docosapentaenoic acid-containing lipid and then fractionating the resultant concentrate into ≤20C components and a 22C main component using reversed phase partition chromatography. n CONSTITUTION: A more highly unsaturated fatty acid or an ester thereof than docosapentaenoic acid-containing lipid extracted from a natural lipid raw material, such as sardine oil, is concentrated and ≤20C components are then removed from the concentrate by reversed phase partition chromatography to afford a fraction consisting essentially of a 22C component. The obtained fraction is subsequently fractionated by reversed phase partition chromatography using methanol containing 5W30vol.% water as an eluent to concentrate and separate the aimed compound of n-3 docosapentaenoic acid and n-6 docosapentaenoic acid which are isomers with a high accuracy. The resultant n-6 docosapentaenoic acid is used as an ameliorant of delta-6 desaturase dysbolism, etc., from linoleic acid to γ-linolenic acid. n COPYRIGHT: (C)1989,JPO&Japio
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