http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H01168698-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4feda2a82a4adcd92a7619df2248333 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 |
| filingDate | 1987-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2a56aefa974eb1d4935f894ec5236b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a172b7246c8d362dcfa700d9a798db8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfe45276d6a63369d3a3e832d400bd93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd3c0345c01da10910d434bb41dc7729 |
| publicationDate | 1989-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H01168698-A |
| titleOfInvention | Production of physiologically active substances of 4949 |
| abstract | PURPOSE: To chemically synthesize the title active substance having inhibitory activity of aminopeptidase B and useful as an immunotherapy agent for malignant tumors, by catalytically reducing a compound with a specified structure and further, removing protecting groups. n CONSTITUTION: A compound expressed by formula I [R 1 is H, alkyl or acyl. R 2 is H, OH or acyloxy. R 3 and R 4 are H, alkyl or amino-protecting group. X is carbamoyl, oxyalkyl or -COOR 5 (R 5 is H or alkyl). Y is carbamoyl, oxyalkyl or -COOR 6 (R 6 is H or carboxyl-protecting group)] is catalytically reduced and protecting groups are removed according to requiring to provide an aimed active substance represented by formula II [R 3 ' and R 4 ' are H, alkyl or amino-protecting group. Y' is carbamoyl, oxyaminoalkyl or -COOR 6 ' (R 6 ' is H or carboxyl-protecting group)]. In addition, the catalytic reduction is preferably carried out by respectively using palladium black, etc., as the catalyst and methanol, etc., as the solvent at ordinary temperature. n COPYRIGHT: (C)1989,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006054396-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4753120-B2 |
| priorityDate | 1987-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.