| abstract |
NEW MATERIAL:The tetralin derivative of formula I [R 1 is OH or carboxy which may be amidated or esterified; R 2 is group of formula II (R 3 , R 4 and R 5 are H, methyl or methoxy) or its hydroquinone compound); n is 1W10]. n EXAMPLE: 1-(3,4-Dimethoxy-6-methyl-2,5-benzoquinonyl)-1,2,3,4-tetrahydro-2- naphthaleneacetic acid. n USE: Useful as a remedy for diseases caused by cerebral hypoxia or anoxia. It can be orally administered. It is effective at a low dose and has low toxicity. Useful e.g., for the treatment of senile dementia such as dysmnesia. n PREPARATION: The compound of formula I is produced by reacting α-tetralone with diethyl carbonate in the presence of a base, reacting the product with a compound of formula III (X is halogen; R 8 is lower alkyl), hydrolyzing the product and subjecting the hydrolyzate to several steps such as decarbonation reaction and reduction. n COPYRIGHT: (C)1989,JPO&Japio |