| abstract |
NEW MATERIAL:Compounds expressed by formula I [X is N, C-Z (Z is H or halogen); Y 1 is Z or (lower alkyl, etc., -substituted) amino; Y 2 is Z; R 1 is (lower alkyl, etc., -substituted) phenyl; R 2 is H, lower alkyl or lower alkenyl having a substituent group, such as 1W2 amino groups, etc. ; n is 0W2, except when X is C-H; Y 1 is H, Y 2 is F; R 1 is ethyl; R 2 is 2-aminoethyl; n is 0]. n EXAMPLE: 7-[(2-Aminoethyl)thio]-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid. n USE: Used as an antimicrobial agent in medicines for humans and animals, drugs for fishes, agricultural chemicals and preservatives, etc., for foods. n PREPARATION: For example, a compound expressed by formula II [Y 3 is halogen; R 3 is H or lower alkyl) is reacted with mercaptans expressed by the formula R 2 -SH in an inert solvent in the presence of a base to afford the aimed compounds expressed by formula I. n COPYRIGHT: (C)1989,JPO&Japio |