| abstract |
NEW MATERIAL: An indenofuran derivative expressed by formula I [R is H or group of formula II which may be optionally substituted on the phenyl ring by alkyl, OH or alkoxy (wherein the alkyl group contains up to 5 carbon atoms)]. n EXAMPLE: 2a,4,4a,5,6,7,7a-octahydroindeno[7,7a,1bc]furan-2,3-dione. n USE: Intermediates for synthesizing Ginkgolides and analogous derivatives having a PAF-Acether antagonist activity. n PROCESS: The compound of formula I, wherein R is H, is obtained by allowing 1,2,3,4-tetrahydro-phenylacetoacetic acid to react with manganese acetate in the presence of an excess of acetic acid and acetic anhydride. n COPYRIGHT: (C)1989,JPO |