| abstract |
NEW MATERIAL:A compound shown by shown by formula I [A is 0, S or SO; R 1 is H or methyl; R 2 is group shown by formula II or formula III (B is O, S, etc.; R 3 WR 8 are H, 1W4C alkyl, halogen, etc.; n is 1W4)] and a nontoxic salt thereof. n EXAMPLE: 4-[2-[4-(4-Isobutylbenzylamino)benzoylamino]phenoxy]butanoic acid. n USE: 5α-Reductase inhibitor useful for treating and preventing diseases (alopecia, acne or prostatic hypertrophy, etc.) caused by excess production of dihydrosterone. n PREPARATION: A compound shown by formula IV (R' is 1W4C alkyl; A' is O, S, etc.) is hydrolyzed (saponified) to give a compound shown by formula I (A=A'). The reaction is carried out in an organic solvent such as dimethoxyethane by using an aqueous solution of an alkali (e.g. lithium hydroxide) usually at -10°CW100°C. n COPYRIGHT: (C)1989,JPO&Japio |