| abstract |
NEW MATERIAL:N-(beta-Chloro-4-methylcinnamoyl)-L-phenylalanine expressed by the formula. USE:An absorbefacient, useful for pharmaceutically active substances, especially absorbefacient for insulin and having excellent effects and safety. PREPARATION:L-Phenylalanine is reacted with beta-chloro-4-methylcinnamoyl chloride in the presence of sodium hydroxide in a solvent, such as acetone, at ordinary temperature to afford the aimed compound expressed by the formula. The above-mentioned compound as an active ingredient is blended and a pharmaceutical is prepared by a conventional method and administered in 0.2-2,000mg dose a day. This absorbefacient is used in an amount of, e.g. 0.1-2,000mg based on 25 units insulin. |