| abstract |
NEW MATERIAL: The compd. of formula I [(n) is 1 or 2; R is H, a substituted 1-21C aliphatic group, a (substituted) 3-20C alicyclic group, a (substituted) 6-12C aliphatic group, a (substituted) 3-20C alicyclic group, a (substituted) 4-20C alicyclic-aliphatic group or the like; R 2 and R 3 are H, a (substituted) 1-21C aliphatic group, a (substituted) 3-20C alicyclic group, a (substituted) 6-12C aromatic group or the formula II [R 4 is H, a 1-6C aliphatic group or the like), etc., where at least either R 3 or R 4 is the formula II]. n EXAMPLE: 5-Methyl-1,3-dioxoleci-2-one-4-ylmethyl2-[N-(1S-ethoxycarbonyl-3- phenylpropyl)-S-alanyl]-(1S,3S,5S)-2-azabicyclo[3,3,0]octane-3-carboxylate. n USE: It is useful as the prodrugs of angiotensin conversion enzyme inhibitors, agents for treating hypertension, agents for treating Alzheimer's diseases or the like. n PREPARATION: A compd. of formula III is reacted with a compd. of formula IV (X is Br or the like) under the conditions of nucleophilic substitution reaction. n COPYRIGHT: (C)1989,JPO |