| abstract |
NEW MATERIAL:A compound expressed by formula I (R 1 and R 2 represent H or 1W5C alkyl; R 3 represents 1W5C alkyl optionally containing halogen, alkenyl or 3W6C cycloalkylmethyl; A represents H or nucleophilic compound's residue) and salt thereof. n EXAMPLE: (6R,7R)7-[(Z)-2-(2-Aminothiazol-4-yl)-2-(1-methoxy-5-hydroxy-4-pyridon-2- yl)methoxyiminoacetamido]-3-(1,2,3-thiadiazol-5-yl)thiomethyl-ceph-3-em-4- carboxylic acid. n USE: An antimicrobial agent useful for Gram-positive bacteria and Gram-negative bacteria including Pseudomonas aeruginosa, which also has powerful action against β-latamase-producing bacteria. n PREPARATION: A compound expressed by formula II (R 10 represents H or amino- protecting group) or reactive derivative thereof is reacted with a compound expressed by formula III (R 11 represents H or carboxy-protecting group), etc., followed by elimination of protecting groups. n COPYRIGHT: (C)1989,JPO&Japio |