| abstract |
NEW MATERIAL: A compound expressed by formula I (X represents formula II, III or the like, each of Y and Q represents CH 2 O, S or the like, each of (m) and (n) represents an integer of 1-4, each of (r), (t)-(v) represents 0, 1 or 2, (p) represents 1, 2 or 3, each of (a)-(d) represents an integer of 0-3, T represents H, a lower alkyl, an alkoxy or the like, each of R 1 , R 4 and R 5 represents H, a lower alkyl and further R 1 represents a haloalkyl or the like, each of R 2 and R 3 represents a lower alkyl, a benzyl and further R 3 represents a naphthyl methyl or the like, R 6 represents a cycloalkyl alkyl, a phenyl alkyl or the like). n EXAMPLE: 3-(Morpholinocarbonyl)-2-(R,S)-(1-naphthylmethyl)propinyl-L-leucine amide of (2S,3R)-2-amino-1-cyclohexyl-3,4-dihydroxy butane. n USE: A rennin inhibitor useful or medical care of hypertension. n PREPARATION: The compound expressed by formula I is obtained by coupling a diol expressed by formula II (Boc means butyl oxy carbonyl) with an acid expressed by formula III by a standard peptide coupling method. n COPYRIGHT: (C)1989,JPO |