| abstract |
NEW MATERIAL: A compd. expressed by formula I [wherein X is formula II (Y is CH 2 , O, S, etc.; T is H, lower alkyl, etc.; m and n are each 1 to 4) etc.; A is O or S; R 1 is H, lower alkyl, etc.; R 2 is lower alkyl or benzyl; R 3 is lower alkyl, etc.; R 4 and R 5 are each H, lower alkyl, etc.; R 6 is cycloalkyl, phenyl, etc.]. n EXAMPLE: o-(N-Morpholinocarbonyl)-3-L-phenyllactyl-L-leucineamide of (2S,3R,4 S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane. n USE: Antihypertensive agent, especially useful as a renin inhibitor. n PREPARATION: An allyl acetic acid compd. expressed by formula III is used as the starting material and subjected to ozonization, reduction, alkylation, coupling, etc., to obtain the compd. of formula I. n COPYRIGHT: (C)1989,JPO |