| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 represents amino group having protecting group; R 2 represents cycloalkyl, etc.; R 3 represents H, cyano(lower)alkylthio, etc.; R 4 represents carboxylate, etc.; n is 0W4; B - represents anionic group; l is 0 or 1, provided that l is 0 when R 4 represents carboxylate group, and l is 1 when R 4 represents (esterified) carboxy group]. n EXAMPLE: Benzhydryl (6S,7S)-7-[ 2-(2-tritylaminothiazol-4-yl)-2-methoximinoaceta mido]-3-[(1-pyridinio)methyl]- Δ 3 -0-2-isocephem-4-carboxylate methanesulfonate. n USE: The compound exhibits superior anti-bacterial activity against Gram-positive (negative) bacteria and dextrose-non-fermenting bacteria such as Pseudomonas aeruginosa, etc. n PREPARATION: An amine compound expressed by formula II and a compound expressed by formula III are subjected to amide bond-formation reaction using a condensing agent, etc., at -20W50°C for 30minW10hr. n COPYRIGHT: (C)1989,JPO&Japio |