| abstract |
NEW MATERIAL:A compound of formula I (R 1 , R 2 are lower alkyl, or incorporate along with N atom. to form 1-pyrrolidyl, piperidino; Ar is pyridyl, thienyl, furyl, pirazinyl) and its acid adduct. n EXAMPLE: N-[4-[2-(Dimethylamino)ethoxy]benzyl]-2-pyrazinecarboxamide hydrochloride. n USE: Digestive tract motion activator. n PREPARATION: After the compound of formula II is converted into its acid chloride, anhydride, mixed anhydride, the derivative is allowed to react with a compound of formula III in the presence or in the absence of a base such as pyridine or sodium carbonate, in an inert organic solvent such as ether, benzene or DMF at 0°C to the refluxing temperature of the solvent to give the compound of formula I. n COPYRIGHT: (C)1989,JPO&Japio |