| abstract |
The invention relates to compounds of the formula (I): in which R 1 and R 2 represent hydrogen or deuterium atoms; R 3 represents a hydrogen atom or a —COOH, —OH or —OPO (OH) 2 group; R5 represents a hydrogen atom or an -OH group; wherein at least one of R3 and R5 is different from a hydrogen atom; R3 represents -COOH, -OH or -OPO (OH And R 2 represents a hydrogen atom; when R 5 represents a —OH group, so that R 3 and R 4 represent a hydrogen atom); R 6 represents optionally substituted phenyl, Compounds selected from heteroaryl, cycloalkyl or heterocycloalkyl groups). The present invention also relates to the preparation of the compounds of formula (I) and their therapeutic use as inhibitors and breakers of the estrogen receptor which are particularly useful in the treatment of cancer. [Chemical formula 1] |