http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5219323-B2
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D515-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D291-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D515-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-00 |
| filingDate | 2001-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-5219323-B2 |
| titleOfInvention | Antitumor echinasaidin derivative |
| abstract | This invention relates to compounds of the formula: ##STR00001## wherein: the substituent groups defined by R.sub.1, R.sub.2 are each independently selected of H, C(.dbd.O)R', C.sub.1 C.sub.18 alkyl, C.sub.2 C.sub.18 alkenyl, C.sub.2 C.sub.18 alkynyl, or aryl; each of the R' groups is independently selected from the group consisting of H; OH; NO.sub.2; NH.sub.2; SH; CN; halogen; .dbd.O; C(.dbd.O)H; C(.dbd.O)CH.sub.3; CO.sub.2H; or C.sub.1 C.sub.18 alkyl, C.sub.2 C.sub.18 alkenyl, C.sub.2 C.sub.18 alkynyl, or aryl, each of which, independently, may be substituted with one or more substituents selected from the group consisting of halogen, cyano, hydroxy, nitro, azido; alkanoyl, carboxamido, alkyl, alkenyl, alkynyl, aryloxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, aminoalkyl, carbocylic aryl having 6 or more carbons, and aralkyl; X.sub.2 is OX.sub.1 or N(X.sub.1).sub.2 wherein each X.sub.1 is independently H, C(.dbd.O)R' where R' is as defined, C.sub.1 C.sub.18 alkyl, C.sub.2 C.sub.18 alkenyl, C.sub.2 C.sub.18 alkynyl, aryl, alkoxy, heterocyclyl, or two X.sub.1 groups together form a cyclic substituent on the nitrogen atom, or X.sub.1 is SO.sub.2CH.sub.3 when X.sub.2 is OX.sub.1, or N(X.sub.1).sub.2 is NHCOalkylCOOH, NHBiotin, NH(aa).sub.y where aa is amino acid acyl and Y is 1, 2 or 3 optionally with a amide terminal group, protected NHCOCH(NH.sub.2)CH.sub.2SH, NHCOalkenylaryl substituted with CF.sub.3, or m-methoxycarbonylbenzoylNH; wherein N(X.sub.1).sub.2 is not NH.sub.2; X.sub.3 is selected of OR.sub.1 where R.sub.1 is as defined, CN, (.dbd.O), or H; X.sub.4 is--H or C.sub.1 C.sub.18 alkyl; and X.sub.5 is selected of H, or R.sub.1 where R.sub.1 is as defined; provided that the compound is not ecteinascidin 583 or 597, which are useful for treating tumors. |
| priorityDate | 2000-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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