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filingDate 2001-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-5000826-B2
titleOfInvention Coated implant
abstract An implant, usually a stent, has a coating of a cross-linked water swellable polymer matrix preferably having a dry thickness of at least 0.1 mum, and a pharmaceutically active compound, the polymer having pendant cationic and pendant zwitterionic groups. The active is usually an anionic compound such as a nucleic acid. The polymer is peferably formed from 2-methacyloy-loxyethyl-2'-trimethylammoniumethyl phosphate inner salt, trialkylammoniumalkyl(meth)acrylate and a cross-linkable monomer such as omega-(trialkoxysilyl)alkyl(meth)acrylate, optionally with a termonomer such as a higher alkyl (meth)acrylate. The stent is coated with polymer, cross-linked then contacted with a solution or dispersion of active compound in a solvent which swells the polymer whereby the active is absorbed into the polymer matrix. The stent is delivered by usual means into a body lumen and the actives released over an extended period of time into the wall of the lumen and/or fluid flowing therein.
priorityDate 2000-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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