http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4999226-B2
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-765 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-785 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
filingDate | 1999-07-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2012-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-4999226-B2 |
titleOfInvention | Coumarin and related aromatic polymer prodrugs |
abstract | The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula:wherein:B is H, OH, OSiR13, a residue of an amine-containing target moiety or a residue of a hydroxyl-containing target moiety,G isor CH2;Y1-2 are independently O or S;M is X or Q; where X is an electron withdrawing group and Q is a moiety containing a free electron pair positioned three to six atoms from C(=Y2);R1, R4, R7, R8, R9, R10 and R13 are independently one of hydrogen, C1-6 alkyls, C3-12 branched alkyls, C3-8, cycloalkyls, C1-6 substituted alkyls, C3-8 substituted cycloalkyls, aryls, substituted aryls, aralkyls, C1-6 heteroalkyls, substituted C1-6 heteroalkyls, C1-6 alkoxy, phenoxy, C1-6 heteroalkoxy, except that R1 and R4 can also be a cyano, nitro, carboxyl, acyl, substituted acyl, carboxyalkyl;Ar is a moiety which when included in Formula (I) forms a multi-substituted aromatic hydrocarbon or a multi-substituted heterocyclic group;(m) is zero or one;(n) is zero or a positive integer;(p) is zero, one or two;(q) is three or four; andR11 is a substantially non-antigenic polymer. |
priorityDate | 1998-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 631.