http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4043203-B2

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filingDate 2001-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2008-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2008-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-4043203-B2
titleOfInvention Intermediates for the synthesis of vinylpyrrolidinone cephalosporins with basic substituents
abstract The present invention relates to cephalosporin derivatives of the general formula <CHEM> wherein X is CH or N; R<1> is hydrogen or cyclopentyl; R<2> is a group of formula <CHEM> R<3> is hydrogen, an alkalimetal ion or a tertiary ammonium group; R<4> is hydrogen, an amino protecting group, pyrrolidin-2-ylmethyl, azetidin-3-ylmethyl, iminomethyl, 1-carbamimidoyl; R<5> is hydrogen, dialkylcarbamoyl, omega -hydroxyalkyl, omega -aminoalkyl, pyridinium-1-ylmethyl, 1-hydroxy-3-aminomethyl-propyl or (hydroxy)-(pyrrolidin-2-yl)methyl; R<6> is hydrogen, trifluoromethyl or hydroxy; and R<7> is alkyl, omega -hydroxy-alkyl, cycloalkyl, 3-pyrrolidinyl, 3-azetidinyl, iminomethyl or 1-carbamimidoyl; as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts; the invention is further concerned with the manufacture of compounds of formula I; with their use as pharmaceutically active substances, particularly for the treatment and prophylaxis of infectious diseases, and with pharmaceutical preparations containing a compound of formula I for the treatment and prophylaxis of infectious diseases.
priorityDate 1996-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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Total number of triples: 33.