| abstract |
PCT No. PCT/EP94/02702 Sec. 371 Date Feb. 5, 1996 Sec. 102(e) Date Feb. 5, 1996 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05366 PCT Pub. Date Feb. 23, 1995The present invention is concerned with compounds having the formula <IMAGE> (I) the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is C1-6alkyl, hydroxy, cyano, halo, C1-6alkyloxy, aryloxy, arylmethoxy, C2-6alkenyl, C2-6alkynyl, C1-6alkyl-S-, C1-6alkyl(S=O)-, C1-6alkylcarbonyl; R4 is hydrogen, halo, hydroxy, C1-6alkyl, or C1-6alkyloxy; or R3 and R4 taken together form a bivalent radical; R5 and R6 each independently are hydrogen, halo, hydroxy, C1-6alkyl, C1-6alkyloxy, aryloxy or arylmethoxy; R7 is hydrogen; Alk1 is C2-5alkanediyl; Alk2 is C2-15alkanediyl; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula <IMAGE> (aa) Pharmaceutical compositions, preparations and use as a medicine are described. |